CB9: Lets Start

While the Greek authorities are banning the substance HHC – hexahydrocannabinol and its derivatives, perhaps in a sudden way, cannabis continues to surprise us with its compounds. As we have mentioned before, the cannabis plant is a versatile plant with numerous uses. And yes, recreational use is one of them.

And yes, recreational use is one of them. Maybe the most cannabis friendly approach for citizens, economy and research, would be a proper legalization of the plant by providing accurate information on the effects, or possible side effects, rather than preserving taboos and spreading inaccuracies.

History so far shows that the more THC is blocked, especially in terms of recreational use, the more products will be released that mimic its effects, with unknown health consequences for consumers. In this paper we will discuss the cannabinoid CB9, the effect it has and the possible medical/therapeutic or recreational uses.

CB9 what is it?

Το CB9 είναι ένα από τα 150, περίπου, κανναβινοειδή, που υπάρχει φυσικά στην κάνναβη. Ακόμη είναι υπό μελέτη η εμφάνιση του CB9 στο φυτό της κάνναβης, ωστόσο, είναι γνωστό ότι προέρχεται από τις ενώσεις CBD και THC.

CB9 is found in the cannabis plant and has a similar molecular structure to cannabidiol, involving a 5-molecule carbon chain. However, it has some differences in chemical structure and for this reason, it has a psychoactive effect, unlike cannabidiol.

Origin, and CB9 chemical structure

It is still complicated to extract directly from the plant, but it was already created semi-synthetically based on pure CBD cannabidiol extract (CBD isolate), without changing its properties. As far as the effect of CB9 with the endocannabinoid system is concerned, research is at an early stage, but new horizons will certainly open up in research regarding natural, semi-synthetic or synthetic cannabinoids.

A very interesting fact about CB9 is that it does not crystallize, unlike other cannabinoids. This gives the study of cannabinoids for medical/therapeutic use and also for industrial purposes a new twist in the production of products with longer duration, stability and ease of use.

CB9 Properties

The cannabinoid CB9 is derived from cannabidiol, either as a natural cannabinoid or as a semi-synthetic derivative of CBD extract. CB9 has a similar structure to the cannabinoids CBD and H4CBD, but is distinguished by its psychoactive properties as opposed to cannabidiol which has non-psychoactive effects. On the other hand, both cannabinoids CB9 and CBD appear to have anti-inflammatory, anxiolytic and neuroprotective effects, and have analgesic effects on pain.

Conventional analytical procedures using HPLC (high performance liquid chromatography) may not be sufficient to recognise CB9. It is this obstacle that points to need for improved testing methods in cannabinoids analysis.

CB9 and THC

CB9 might have a mild euphoric effect, much like HHC or D8-THC, but certainly less than tetrahydrocannabinol. Euphoria is the common element. The intensity of the effect is their difference, since CB9 is milder than THC.

What do we already know about CB9?

• It is not a derivative of hexahydrocannabinol / HHC.
• It is a natural cannabinoid, although the market products contain CB9, as a processed form of CBD.
• It is more stable molecule than other cannabinoids, because it does not tend to crystallize.
• It is not related to tetrahydrocannabinol / THC. On the contrary, it has milder effect than THC.
• Does not dry out the throat when smoking or vaping, as it does with H4CBD
• It has mild psychoactive effects.

How does CB9 affect the endocannabinoid system?

Cannabinoids are known to interact differently with the human endocannabinoid system due to the unique structure of each one. At the same time, this interaction has a different effect from organism to organism.

 So far, the data show that the endocannabinoid system is involved in various bodily functions such as sleep, appetite, mood, regulation of the immune and neurological systems. There are two major cannabinoid receptors, CB1 and CB2, located in different body parts, such as the brain, nervous, digestive, immune system, and other body organs.

Cannabidiol has low binding to these receptors and, therefore, lacks psychoactive effects. Concerning CB9, research is still at an early stage, but it has already started, leading to a new era of promising results.

Therapeutic properties and applications

Cannabinoids have many applications both in the medical / therapeutic sector, or for industrial and recreational use. Whether referring to natural cannabinoids, semi-synthetic or synthetic, they are already under the microscope of many laboratories for their potential therapeutic / pharmaceutical uses and applications in various disorders.

Even from a recreational perspective, cannabinoids present great interest, as each one has a different effect on the body, considering also the preferred or suggested cannabinoid mix.

CB9 seems to be one of the cannabinoids that enhances its function when combined with other cannabinoids. Moreover, thanks to its mild psychoactive effects, it may be beneficial in cases of anxiety, stress, pain, and sleep-related disorders.

Potential CB9 properties

• Euphoria
• Feeling of relaxation
• Mild alteration of perception
• Anti-inflammatory effect
• Soothing, analgesic effect
• Stress relief

CB9 products, availability

The market for CB9 products is still at an early stage as with all new cannabinoids. However, the first CB9 products have already started to appear and the sector could flourish in Greece. So far, there is CB9 extract, which is derived from processing cannabidiol CBD extract, cannabis flowers, CB9 vape pens ( CB9 vaping pens) and much more is expected.

Up to day, we know that cannabis will never cease to amaze us with the beneficial properties it can have in several disorders and conditions of the body.

More research is certainly required to provide information about the effects of CB9 and other cannabinoids or compounds detected in cannabis plants.

However, as the market in cannabis products evolves, new opportunities appear for consumers, companies and the research field. The more data collected by the laboratories, the better and safer the results will get concerning cannabis cannabinoids and other chemical compounds, whether it will be for therapeutic, industrial or recreational use.

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